The circulating levels of CTRP1 and CTRP5 are associated with obesity indices and carotid intima-media thickness (cIMT) value in patients with type 2 diabetes: a preliminary study

Abstract Background There is growing evidence that the C1qTNF-related protein (CTRP) family has a crucial role in pathophysiology of metabolic disorders such as type 2 diabetes (T2D) and obesity. We sought to identify association CTRP1 CTRP5 circulating levels with various obesity parameters visceral adipose tissue (VAT) thickness, adiposity index (VAI), carotid intima-media thickness (cIMT) patients T2D controls. Methods This preliminary study consisted men (n = 42) without 42). The measurement cIMT VAT was performed using an Accuvix XQ ultrasound. Circulating CTRP1, CTRP5, adiponectin were measured by enzyme-linked immunosorbent assay (ELISA). Results CTRP-1 CTRP1/CTRP5 ratio markedly higher compared controls (p < 0001 p 0004 respectively). Interestingly, binominal logistic regression revealed level associated presence (odds [OR]: 1.009 [95% CI: 1.004–1.015]; P .001). correlated WHR, VAT, HOMA-IR whole population study. Also, we observed plasma (? 0.648, 0.005) 0.444, 0.049) are independently value. Conclusions Our results indicated concentrations atherosclerosis these adipokines might have causal for cardiometabolic risk T2D.However, more studies large sample sizes required clarify CTRPs pathogenesis.